Use case

ClinicalGenomics

Reference	Userreq.ClinicalGenomics
High-level reqs
Proposed by	Alex May

	Taverna 1.3	Taverna 2.0
Priority

Overview

Type 2 diabetes is a major and increasing determinant of chronic kidney disease (CKD), cardiovascular disease and premature mortality. There is an exceptional, longstanding collection of biological, clinical and social data on people with diabetes in the UK city of Salford. The Salford Diabetes Register, established in 1992, is a population-based, shared-care electronic diabetes management system. The system covers patients cared for in both primary and secondary care settings.

Recently, the Salford Diabetes Register has been used to guide the construction of two collections of DNA samples - one for patients with diabetes (N= 1800), the other for those with CKD (N = 1200). The collections are currently being employed to identify single nucleotide polymorphisms (SNPs) contributing to these multigenic diseases.

Overall Goals

construct a 'workflow' approach to analyse and manage the SNP analysis.

Required services

Workflow outline

Appendix